10779/rcsi.10766561.v1 Amos Matsiko Amos Matsiko Tanya J. Levingstone Tanya J. Levingstone John P. Gleeson John P. Gleeson Fergal O'Brien Fergal O'Brien Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential. Royal College of Surgeons in Ireland 2019 Articular cartilage collagen-based scaffolds growth factor delivery mesenchymal stem cells transforming growth factor-beta 3 Anatomy 2019-11-22 15:12:31 Journal contribution https://repository.rcsi.com/articles/journal_contribution/Incorporation_of_TGF-beta_3_within_collagen-hyaluronic_acid_scaffolds_improves_their_chondrogenic_potential_/10766561 <p>Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen-hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.</p>