10779/rcsi.10766561.v1
Amos Matsiko
Amos
Matsiko
Tanya J. Levingstone
Tanya J.
Levingstone
John P. Gleeson
John P.
Gleeson
Fergal O'Brien
Fergal
O'Brien
Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential.
Royal College of Surgeons in Ireland
2019
Articular cartilage
collagen-based scaffolds
growth factor delivery
mesenchymal stem cells
transforming growth factor-beta 3
Anatomy
2019-11-22 15:12:31
Journal contribution
https://repository.rcsi.com/articles/journal_contribution/Incorporation_of_TGF-beta_3_within_collagen-hyaluronic_acid_scaffolds_improves_their_chondrogenic_potential_/10766561
<p>Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen-hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.</p>