Rohde, Daniela Professor, Anne Hickey Williams, David Bennett, Kathleen Cognitive impairment and cardiovascular medication use: Results from wave 1 of The Irish Longitudinal Study on Ageing. <p><strong>AIM:</strong> To explore the association between cardiovascular medication use and cognitive impairment in adults aged 50 years and over.</p> <p><strong>METHOD:</strong> This cross-sectional linked database study involved secondary quantitative analysis of 1903 participants from wave 1 of the Irish Longitudinal Study on Ageing with available pharmacy claims data. Cognitive impairment was assessed using a cut-off of ≤23 on the Montreal Cognitive Assessment. Cardiovascular medication use was calculated using the proportion of days covered for antihypertensive, antithrombotic, and lipid-modifying medications. For each class of cardiovascular medication, participants were categorized as belonging to one of three medication use groups: (1) not dispensed any medications (reference); (2) poor adherence (proportion of days covered</p> <p><strong>RESULTS:</strong> Controlling for demographic and health variables, there was no evidence of an independent association between impaired cognitive function and use of antihypertensives [good adherence OR (95% CI): 1.16 (0.88, 1.52), poor adherence OR (95% CI): 1.39 (0.95, 2.04)]; antithrombotics [good adherence OR (95% CI): 1.26 (0.93, 1.70), poor adherence OR 95% CI): 1.13 (0.80, 1.59)]; or lipid-modifying agents [good adherence OR (95% CI): 0.95 (0.71, 1.25), poor adherence OR (95% CI): 0.88 (0.64, 1.22)].</p> <p><strong>CONCLUSION:</strong> We found no evidence of an association between cardiovascular medication use and cognitive function. Future studies should investigate the prospective associations between cognition and use of cardiovascular medications using longitudinal data.</p> Aged;Cardiovascular diseases;Cognition disorders;Dyslipidemia;Hypertension;Medication adherence.;Psychology and Cognitive Sciences not elsewhere classified 2019-11-22
    https://repository.rcsi.com/articles/journal_contribution/Cognitive_impairment_and_cardiovascular_medication_use_Results_from_wave_1_of_The_Irish_Longitudinal_Study_on_Ageing_/10771268