Adjusted prognostic association of post-myocardial infarction depression withmortality and cardiovascular events: an individual patient data meta-analysis MeijerAnna ConradiHenk Jan BosElske H. AnselminoMatteo CarneyRobert M. DenolletJohan DoyleFrank FreedlandKenneth E. GraceSherry L. HosseiniSeyed Hamzeh LaneDeirdre A. PiloteLouise ParakhKapil RafanelliChiara SatoHiroshi SteedsRichard P. WelinCatharina de JongePeter 2019 <p><strong>Background:</strong> The association between depression after myocardial infarction (post-MI) and increased risk of mortality and cardiac morbidity may be due to cardiac disease severity.</p> <p><strong>Aims:</strong> To combine original data from studies on the association between post-MI depression and prognosis into one database. To investigate to what extent post-MI depression predicts prognosis independently of disease severity.</p> <p><strong>Method: </strong>Individual patient data meta-analysis of studies, using multilevel, multivariable Cox regression analyses.</p> <p><strong>Results:</strong>Sixteen studies participated, creating a database of 10,175 post-MI patients. HRs for post-MI depression were 1.32 (95%CI 1.26-1.38, p</p> <p><strong>Conclusions:</strong> The association between post-MI depression and prognosis is attenuated after adjustment for cardiac disease severity. Still, depression remains independently associated with prognosis, with a 22% increased risk of all-cause mortality and a 13% increased risk of cardiovascular events per standard deviation in depression z-score.</p> <p><strong>Declaration of interest:</strong> None.</p>