10779/rcsi.10781696.v1
Gianpiero Cavalleri
Gianpiero
Cavalleri
Slave Petrovski
Slave
Petrovski
Mary Fitzsimons
Mary
Fitzsimons
Norman Delanty
Norman
Delanty
eHealth as a Facilitator of Precision Medicine in Epilepsy
Royal College of Surgeons in Ireland
2019
eHealth
Epilepsy
Precision Medicine
Clinical Pharmacology and Therapeutics
2019-11-22 16:15:40
Journal contribution
https://repository.rcsi.com/articles/journal_contribution/eHealth_as_a_Facilitator_of_Precision_Medicine_in_Epilepsy/10781696
<p>Epilepsy is a chronic neurological condition that affects approximately 50 million people worldwide. Current treatments are inadequate and around a third of patients continue to experience uncontrolled seizures. The genetic architecture of many of the epilepsies makes them amenable to next-generation sequencing technologies, enabling a molecular diagnosis in an increasing proportion of patients. As a result, rare but remarkable examples of precision therapeutics in epilepsy are emerging. Coordinated research efforts are required to increase the diagnostic yield of sequencing and translate diagnosis to improved prognosis. This review explores the potential of eHealth technologies in facilitating and accelerating precision therapeutics in epilepsy. We describe the state of the art in precision diagnostics and therapeutics in epilepsy and identify opportunities for eHealth to accelerate the realisation of precision therapeutics via patient registries, research-enabled electronic health records, and connected health solutions.</p>