10779/rcsi.10782017.v1 Michelle Lavin Michelle Lavin Sonia Aguila Sonia Aguila Niall Dalton Niall Dalton Margaret Nolan Margaret Nolan Mary Byrne Mary Byrne Kevin Ryan Kevin Ryan Barry White Barry White Niamh M. O'Connell Niamh M. O'Connell Jamie O'Sullivan Jamie O'Sullivan Jorge Di Paola Jorge Di Paola Paula D. James Paula D. James James S. O'Donnell James S. O'Donnell Significant gynecological bleeding in women with low von Willebrand factor levels. Royal College of Surgeons in Ireland 2019 von Willebrand’s disease menorrhagia bleeding disorder. Clinical Pharmacology and Therapeutics 2019-11-22 16:17:25 Journal contribution https://repository.rcsi.com/articles/journal_contribution/Significant_gynecological_bleeding_in_women_with_low_von_Willebrand_factor_levels_/10782017 <p>Gynecological bleeding is frequently reported in women with von Willebrand disease (VWD). Low von Willebrand factor (VWF) may be associated with significant bleeding phenotype despite only mild plasma VWF reductions. The contribution of gynecological bleeding to this phenotype has yet to be described. The optimal clinical bleeding assessment tool (BAT) to evaluate bleeding remains unclear. Using a standardized approach to phenotypic assessment, we evaluated gynecological bleeding and directly compared the Condensed Molecular and Clinical Markers for the Diagnosis and Management of type 1 VWD (Condensed MCMDM-1 VWD) and International Society on Thrombosis and Haemostasis (ISTH) BAT scores in 120 women enrolled in the Low von Willebrand in Ireland Cohort study. Heavy menstrual bleeding (HMB) was reported in 89% of female participants; 45.8% developed iron deficiency. Using identical data, Condensed MCMDM-1 VWD menorrhagia domain scores were significantly lower than ISTH BAT scores (2 vs 3;</p>