10779/rcsi.10782713.v1
Paul A. MacMullan
Paul A.
MacMullan
Geraldine M. McCarthy
Geraldine M.
McCarthy
The meniscus, calcification and osteoarthritis: a pathologic team.
Royal College of Surgeons in Ireland
2019
Calcinosis
Calcium
Calcium Phosphates
Calcium Pyrophosphate
Cartilage
Articular
Crystallization
Humans
Osteoarthritis
Clinical Pharmacology and Therapeutics
2019-11-22 16:20:39
Journal contribution
https://repository.rcsi.com/articles/journal_contribution/The_meniscus_calcification_and_osteoarthritis_a_pathologic_team_/10782713
Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification are upregulated in OA meniscal cells. Also, this in vitro calcium deposition by OA menisci is inhibited by phosphocitrate. This study should catalyse further work examining the pathological contribution or otherwise of calcium crystals in OA. This would significantly aid the development of potential disease modifying agents in OA, which are currently unavailable.