A novel platinum complex of the histone deacetylase inhibitor belinostat: rational design, development and in vitro cytotoxicity.
James P. Parker
Hassan Nimir
Darren M. Griffith
Brian Duff
Anthony J. Chubb
Marian P. Brennan
Maria Morgan
Denise Egan
Celine Marmion
10779/rcsi.10783361.v1
https://repository.rcsi.com/articles/journal_contribution/A_novel_platinum_complex_of_the_histone_deacetylase_inhibitor_belinostat_rational_design_development_and_in_vitro_cytotoxicity_/10783361
<p>The successful design and synthesis of a novel Pt complex of the histone deacteylase inhibitor belinostat are reported. Molecular modelling assisted in the identification of a suitable malonate derivative of belinostat (mal-p-Bel) for complexation to platinum. Reaction of [Pt(NH3)2(H2O)2](NO3)2 with the disodium salt of mal-p-Bel gave cis-[Pt(NH3)2(mal-p-Bel-2H)] (where -2H indicates that mal-p-Bel is doubly deprotonated) in excellent yield. An in vitro cytotoxicity study revealed that cis-[Pt(NH3)2(mal-p-Bel-2H)] possesses (i) considerable cytotoxicity against reported ovarian cancer cell lines, (ii) enhanced cytotoxicity relative to the previously reported Pt histone deacetylase inhibitor conjugate, cis-[Pt(II)(NH3)2(malSAHA-2H)] and (iii) favourable cyto-selective properties as compared to cisplatin and belinostat.</p>
2019-11-22 16:23:43
cancer
histone deacetylase
belinostat
platinum
drug
treatment
Clinical Pharmacology and Therapeutics