10779/rcsi.10783841.v1
Robin J. Hennessy
Robin J.
Hennessy
Patrizia A. Baldwin
Patrizia A.
Baldwin
David J. Browne
David J.
Browne
Anthony Kinsella
Anthony
Kinsella
John L. Waddington
John L.
Waddington
Three-dimensional laser surface imaging and geometric morphometrics resolve frontonasal dysmorphology in schizophrenia.
Royal College of Surgeons in Ireland
2019
Adult
Cephalometry
Craniofacial Abnormalities
Diagnostic Imaging
Female
Humans
Image Processing
Computer-Assisted
Imaging
Three-Dimensional
Lasers
Male
Middle Aged
Nose
Reference Values
Schizophrenia
Sex Factors
Clinical Pharmacology and Therapeutics
2019-11-22 16:26:14
Journal contribution
https://repository.rcsi.com/articles/journal_contribution/Three-dimensional_laser_surface_imaging_and_geometric_morphometrics_resolve_frontonasal_dysmorphology_in_schizophrenia_/10783841
<p>BACKGROUND: Although a role for early developmental disturbance(s) in schizophrenia is postulated, it has proved difficult to identify hard, biological evidence. The brain and face emerge in embryologic intimacy, such that in neurodevelopmental disorders, brain dysmorphogenesis is accompanied by facial dysmorphogenesis. METHODS: Three-dimensional (3D) laser surface imaging was used to capture the facial surface of patients and control subjects in 37 male and 32 female patients who satisfied DSM-IV criteria for schizophrenia in comparison with 58 male and 34 female control subjects. Surface images were analyzed using geometric morphometrics and 3D visualizations to identify domains of facial shape that distinguish patients from control subjects. RESULTS: Both male and, particularly, female patients evidenced significant facial dysmorphology. There was narrowing and reduction of the mid to lower face and frontonasal prominences, including reduced width and posterior displacement of the mouth, lips, and chin; increased width of the upper face, mandible, and skull base, with lateral displacement of the cheeks, eyes, and orbits; and anterior displacement of the superior margins of the orbits. CONCLUSIONS: The frontonasal prominence, which enjoys the most intimate embryologic relationship with the anterior brain and also orchestrates aspects of development in maxillary and mandibular domains, evidences a characteristic topography of dysmorphogenesis in schizophrenia.</p>