10779/rcsi.10783841.v1 Robin J. Hennessy Robin J. Hennessy Patrizia A. Baldwin Patrizia A. Baldwin David J. Browne David J. Browne Anthony Kinsella Anthony Kinsella John L. Waddington John L. Waddington Three-dimensional laser surface imaging and geometric morphometrics resolve frontonasal dysmorphology in schizophrenia. Royal College of Surgeons in Ireland 2019 Adult Cephalometry Craniofacial Abnormalities Diagnostic Imaging Female Humans Image Processing Computer-Assisted Imaging Three-Dimensional Lasers Male Middle Aged Nose Reference Values Schizophrenia Sex Factors Clinical Pharmacology and Therapeutics 2019-11-22 16:26:14 Journal contribution https://repository.rcsi.com/articles/journal_contribution/Three-dimensional_laser_surface_imaging_and_geometric_morphometrics_resolve_frontonasal_dysmorphology_in_schizophrenia_/10783841 <p>BACKGROUND: Although a role for early developmental disturbance(s) in schizophrenia is postulated, it has proved difficult to identify hard, biological evidence. The brain and face emerge in embryologic intimacy, such that in neurodevelopmental disorders, brain dysmorphogenesis is accompanied by facial dysmorphogenesis. METHODS: Three-dimensional (3D) laser surface imaging was used to capture the facial surface of patients and control subjects in 37 male and 32 female patients who satisfied DSM-IV criteria for schizophrenia in comparison with 58 male and 34 female control subjects. Surface images were analyzed using geometric morphometrics and 3D visualizations to identify domains of facial shape that distinguish patients from control subjects. RESULTS: Both male and, particularly, female patients evidenced significant facial dysmorphology. There was narrowing and reduction of the mid to lower face and frontonasal prominences, including reduced width and posterior displacement of the mouth, lips, and chin; increased width of the upper face, mandible, and skull base, with lateral displacement of the cheeks, eyes, and orbits; and anterior displacement of the superior margins of the orbits. CONCLUSIONS: The frontonasal prominence, which enjoys the most intimate embryologic relationship with the anterior brain and also orchestrates aspects of development in maxillary and mandibular domains, evidences a characteristic topography of dysmorphogenesis in schizophrenia.</p>