Immune, inflammatory and infectious consequences of estrogen in women with cystic fibrosis.
Sanjay H. Chotirmall
Catherine M. Greene
Noel G. McElvaney
10779/rcsi.10784042.v1
https://repository.rcsi.com/articles/journal_contribution/Immune_inflammatory_and_infectious_consequences_of_estrogen_in_women_with_cystic_fibrosis_/10784042
<p>Cystic fibrosis (CF), a multi-system genetic disease with predominantly pulmonary manifestations, occurs due to defective chloride secretion at epithelial surfaces. The consequential sodium hyper-absorption leads to mucus hypersecretion, compromised mucociliary clearance and pathogenic colonization by, for instance, <em>Staphylococcus aureus </em>and/or <em>Pseudomonas aeruginosa</em>. This sequence of events leads to recurrent infection and persistent chronic neutrophilic inflammation causing airway damage, irreversible bronchiectasis, respiratory failure and death.</p>
2019-11-22 16:28:01
Contraceptives
Oral
Hormonal
Cystic Fibrosis
Estradiol
Estrogen Receptor beta
Female
Humans
Interleukin-8
Menstrual Cycle
Pseudomonas aeruginosa
Respiratory Mucosa
Secretory Leukocyte Peptidase Inhibitor
Up-Regulation
Medicine