Immune, inflammatory and infectious consequences of estrogen in women with cystic fibrosis. Sanjay H. Chotirmall Catherine M. Greene Noel G. McElvaney 10779/rcsi.10784042.v1 https://repository.rcsi.com/articles/journal_contribution/Immune_inflammatory_and_infectious_consequences_of_estrogen_in_women_with_cystic_fibrosis_/10784042 <p>Cystic fibrosis (CF), a multi-system genetic disease with predominantly pulmonary manifestations, occurs due to defective chloride secretion at epithelial surfaces. The consequential sodium hyper-absorption leads to mucus hypersecretion, compromised mucociliary clearance and pathogenic colonization by, for instance, <em>Staphylococcus aureus </em>and/or <em>Pseudomonas aeruginosa</em>. This sequence of events leads to recurrent infection and persistent chronic neutrophilic inflammation causing airway damage, irreversible bronchiectasis, respiratory failure and death.</p> 2019-11-22 16:28:01 Contraceptives Oral Hormonal Cystic Fibrosis Estradiol Estrogen Receptor beta Female Humans Interleukin-8 Menstrual Cycle Pseudomonas aeruginosa Respiratory Mucosa Secretory Leukocyte Peptidase Inhibitor Up-Regulation Medicine