Chotirmall, Sanjay H. Greene, Catherine M. McElvaney, Noel G. Immune, inflammatory and infectious consequences of estrogen in women with cystic fibrosis. <p>Cystic fibrosis (CF), a multi-system genetic disease with predominantly pulmonary manifestations, occurs due to defective chloride secretion at epithelial surfaces. The consequential sodium hyper-absorption leads to mucus hypersecretion, compromised mucociliary clearance and pathogenic colonization by, for instance, <em>Staphylococcus aureus </em>and/or <em>Pseudomonas aeruginosa</em>. This sequence of events leads to recurrent infection and persistent chronic neutrophilic inflammation causing airway damage, irreversible bronchiectasis, respiratory failure and death.</p> Contraceptives;Oral;Hormonal;Cystic Fibrosis;Estradiol;Estrogen Receptor beta;Female;Humans;Interleukin-8;Menstrual Cycle;Pseudomonas aeruginosa;Respiratory Mucosa;Secretory Leukocyte Peptidase Inhibitor;Up-Regulation;Medicine 2019-11-22
    https://repository.rcsi.com/articles/journal_contribution/Immune_inflammatory_and_infectious_consequences_of_estrogen_in_women_with_cystic_fibrosis_/10784042