10779/rcsi.10785350.v1
Paul J. McKiernan
Paul J.
McKiernan
Catherine M. Greene
Catherine M.
Greene
MicroRNA Dysregulation in Cystic Fibrosis.
Royal College of Surgeons in Ireland
2019
Cystic fibrosis
endoplasmic reticulum stress
in vivo study
inflammation
innate immunity
ion conductance
lung disease
nonhuman
pathogenesis
pathophysiology
pneumonia
primary cell culture
priority journal
protein defect
protein expression
Review
RNA processing
Medicine
2019-11-22 16:34:35
Journal contribution
https://repository.rcsi.com/articles/journal_contribution/MicroRNA_Dysregulation_in_Cystic_Fibrosis_/10785350
<p>The cystic fibrosis lung is a complex milieu comprising multiple factors that coordinate its physiology. MicroRNAs are regulatory factors involved in most biological processes and it is becoming increasingly clear that they play a key role in the development and manifestations of CF lung disease. These small noncoding RNAs act posttranscriptionally to inhibit protein production. Their involvement in the pathogenesis of CF lung disease stems from the fact that their expression is altered in vivo in the CF lung due to intrinsic and extrinsic factors; to date defective chloride ion conductance, endoplasmic reticulum stress, inflammation, and infection have been implicated in altering endogenous miRNA expression in this setting. Here, the current state-of-the-art and biological consequences of altered microRNA expression in cystic fibrosis are reviewed.</p>