10.25419/rcsi.10785458.v1 Michelle M. White Michelle M. White Fatma Gargoum Fatma Gargoum Niall Browne Niall Browne Killian Hurley Killian Hurley Noel G. McElvaney Noel G. McElvaney Emer P. Reeves Emer P. Reeves New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity Royal College of Surgeons in Ireland 2019 Cystic fibrosis cystic fibrosis transmembrane conductance regulator neutrophil function Medicine 2019-11-22 16:35:04 Chapter https://repository.rcsi.com/articles/chapter/New_Research_on_the_Importance_of_Cystic_Fibrosis_Transmembrane_Conductance_Regulator_Function_for_Optimal_Neutrophil_Activity/10785458 <p>Despite tremendous recent advances in our understanding of the molecular and cellular basis of cystic fibrosis (CF), there remains a paradox of why recruited neutrophils fail to eradicate bacterial infections in the airways of individuals with CF. The focus of this chapter is on new research authenticating the CF neutrophil as a key player in disease pathogenesis. Studies specifying intrinsic abnormalities due to a lack of cystic fibrosis transmembrane conductance regulator (CFTR) function, along with reports indicating reprogrammed cell activity secondary to chronic bacterial infection and inflammation, will be discussed.</p>