10.25419/rcsi.10785458.v1
Michelle M. White
Michelle M.
White
Fatma Gargoum
Fatma
Gargoum
Niall Browne
Niall
Browne
Killian Hurley
Killian
Hurley
Noel G. McElvaney
Noel G.
McElvaney
Emer P. Reeves
Emer P.
Reeves
New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity
Royal College of Surgeons in Ireland
2019
Cystic fibrosis
cystic fibrosis transmembrane conductance regulator
neutrophil function
Medicine
2019-11-22 16:35:04
Chapter
https://repository.rcsi.com/articles/chapter/New_Research_on_the_Importance_of_Cystic_Fibrosis_Transmembrane_Conductance_Regulator_Function_for_Optimal_Neutrophil_Activity/10785458
<p>Despite tremendous recent advances in our understanding of the molecular and cellular basis of cystic fibrosis (CF), there remains a paradox of why recruited neutrophils fail to eradicate bacterial infections in the airways of individuals with CF. The focus of this chapter is on new research authenticating the CF neutrophil as a key player in disease pathogenesis. Studies specifying intrinsic abnormalities due to a lack of cystic fibrosis transmembrane conductance regulator (CFTR) function, along with reports indicating reprogrammed cell activity secondary to chronic bacterial infection and inflammation, will be discussed.</p>