10.25419/rcsi.10786730.v1
Andrea Armani
Andrea
Armani
Vincenzo Marzolla
Vincenzo
Marzolla
Alessandra Feraco
Alessandra
Feraco
Stefania Gorini
Stefania
Gorini
Caterina Mammi
Caterina
Mammi
Marco Infante
Marco
Infante
Massimiliano Caprio
Massimiliano
Caprio
Mineralocorticoid Receptor in Novel Target Tissues: A Closer Look at the Adipocyte
Royal College of Surgeons in Ireland
2019
adipose tissue
autophagy
browning
insulin resistance
obesity
Molecular Medicine
2019-11-22 16:40:18
Chapter
https://repository.rcsi.com/articles/chapter/Mineralocorticoid_Receptor_in_Novel_Target_Tissues_A_Closer_Look_at_the_Adipocyte/10786730
<p>In addition to the well-documented role in the kidney, the mineralocorticoid receptor (MR) has been recently identified in different “non-classical” target tissues, such as the brain, the heart, vasculature, macrophages/monocytes, and adipose tissue. In this context, the MR is involved in adipocyte fundamental processes such as differentiation, autophagy, and adipokine secretion. Excessive activation of the MR contributes to metabolic derangements occurring in mice with obesity and metabolic syndrome. Interestingly, MR pharmacological blockade in murine models of obesity has led to protection from weight gain and adipocyte dysfunctions. Unfortunately, there is still a lack of knowledge on the metabolic effects of MR antagonists, and larger clinical studies are deemed necessary to clarify the metabolic role of MR blockade in humans. This review discusses the role of MR in adipose tissue, focusing on regulation by MR of key cellular processes occurring in the adipocyte. The molecular pathways affected by MR activation or blockade in adipose tissue have been investigated only in part. Hence, more studies are necessary to get more insights in the role of aldosterone/MR in this “non-classical” target tissue and to better understand its potential implications in obesity and metabolic syndrome.</p>