10.25419/rcsi.10786802.v1
Diego Alvarez de la Rosa
Diego Alvarez
de la Rosa
Natalia Serrano-Morillas
Natalia
Serrano-Morillas
Post-Translational Modification of MR Activity
Royal College of Surgeons in Ireland
2019
mineralocorticoid receptor
aldosterone
glucocorticoids. steroid receptors
protein modification
phosphorylation
Ubiquitylation
SUMOylation
acetylation
Molecular Medicine
2019-11-22 16:40:51
Chapter
https://repository.rcsi.com/articles/chapter/Post-Translational_Modification_of_MR_Activity/10786802
<p>The mineralocorticoid receptor (MR) is a ligand-activated transcription factor that transduces the effects of aldosterone and glucocorticoids in a tissue- and cell type-specific ways. Differential regulation of MR by post-translational modifications (PTMs) has been proposed to play a key role in modulating its function. In addition, modifications of other proteins that physically or functionally interact with MR add an additional layer of regulation to aldosterone or glucocorticoid signaling. In this chapter, we will summarize the main post-translational modifications of MR described so far, discussing their possible implications in the physiological and pathological roles of the receptor. We will also discuss post-translational modulation of other proteins impacting MR function such as heat shock protein 90 or 11ß-hydroxysteroid dehydrogenase type 2.</p>