Non-genomic actions of aldosterone: From receptors and signals to membrane targets. Ruth Dooley Brian J. Harvey Warren Thomas 10779/rcsi.10787066.v1 https://repository.rcsi.com/articles/journal_contribution/Non-genomic_actions_of_aldosterone_From_receptors_and_signals_to_membrane_targets_/10787066 <p>In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na(+) channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid 'non-genomic' activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation.</p> 2019-11-22 16:42:17 Aldosterone Non-genomic Mineralocorticoid Receptor ENaC Kidney Protein Kinase D Molecular Medicine