10779/rcsi.10787192.v1
Cormac J. Jennings
Cormac J.
Jennings
Paul M. Walsh
Paul M.
Walsh
Sandra Deady
Sandra
Deady
Brian J. Harvey
Brian J.
Harvey
Warren Thomas
Warren
Thomas
Malignant pleural mesothelioma incidence and survival in the Republic of Ireland 1994-2009.
Royal College of Surgeons in Ireland
2019
Mesothelioma
Asbestos
Incidence
Survival
Occupational health
Ireland.
Molecular Medicine
2019-11-22 16:42:45
Journal contribution
https://repository.rcsi.com/articles/journal_contribution/Malignant_pleural_mesothelioma_incidence_and_survival_in_the_Republic_of_Ireland_1994-2009_/10787192
<p>OBJECTIVE: Malignant pleural mesothelioma (MPM) is a rare malignancy associated with exposure to asbestos. The protracted latent period of MPM means that its incidence has continued to rise across Europe after the introduction of restrictions on asbestos use. In order to obtain a clearer indication of trends in the Republic of Ireland (ROI), incidence and survival were assessed based on all MPM cases reported since the establishment of the National Cancer Registry of Ireland (NCR).</p>
<p>METHODS: NCR recorded 337 MPM diagnoses in the ROI during 1994-2009. Survival was assessed for all cases diagnosed with adequate follow-up (n=330). Crude and European age-standardized incidence rates were calculated for all cases and for 4-year periods. A Cox model of observed (all-cause) survival was used to generate hazard ratios for the effect of: gender; age at diagnosis; diagnosis cohort; region of residence; histological type; and tumour stage. Single P-values for the variables indicated were calculated using either a stratified log-rank test or stratified trend test.</p>
<p>RESULTS: Over the study period the age-standardized MPM incidence in the ROI rose from 4.98cases per million (cpm) to 7.24cpm. The 1-year survival rate for all MPM cases was 29.6% (CI 24.7-34.6%). Excess mortality risk was associated with age at diagnosis (75-89 yrs vs. 55-64 yrs, HR 1.88, 95% CI 1.35-2.63, P</p>
<p>CONCLUSION: MPM incidence and mortality continued to rise in the ROI after the restrictions on asbestos use and the predictors of survival detected in this study are broadly consistent with those identified for other countries.</p>