%0 Journal Article %A Mocanu, Edgar %A Cottell, Evelyn %A Waite, K %A Hennelly, Bernadette %A Collins, Claire %A Harrison, Robert F. %D 2019 %T Frozen-thawed transfer cycles: are they comparable with fresh? %U https://repository.rcsi.com/articles/journal_contribution/Frozen-thawed_transfer_cycles_are_they_comparable_with_fresh_/10787672 %2 https://repository.rcsi.com/ndownloader/files/19300382 %K Cryopreservation %K Embryo Implantation %K Embryo Transfer %K Female %K Fertilization in Vitro %K Humans %K Infertility %K Pregnancy %K Pregnancy Rate %K Multiple %K Reproductive Techniques %K Assisted %K Zygote %K Obstetrics and Gynaecology %X

Cryopreservation of zygotes and subsequent thaw and transfer is an established ART treatment. We assessed if success rates frozen-thawed (day 2) zygotes are comparable with the outcome in fresh cycles of treatment. We performed a prospective follow-up and analysis of all frozen (FZT) and fresh cycles of treatment during a 12 months period. One hundred and nineteen patients in the frozen-thawed and 652 in the fresh group had a transfer. The overall thaw-survival rate was 71.7%. Clinical pregnancy rates per thaw and transfer were respectively 15.1% and 21% in the frozen and 29.1% (per transfer) in the fresh group. Implantation rates in fresh and frozen cycles were 16% and 12.3% respectively. The pregnancy loss rate was higher in the FZT group (29% vs. 18.3%). Cryopreservation of good quality zygotes, after fresh transfer offers optimal success rates in subsequent frozen treatment. It also encourages consideration of elective single zygote transfers.

%I Royal College of Surgeons in Ireland