Selenium Status is Associated with Colorectal Cancer risk in the European Prospective Investigation of Cancer and Nutrition Cohort David J. Hughes Veronika Fedirko Mazda Jenab Lutz Schomburg Catherine Meplan Heinz Freisling H B. Bueno-de-Mesquita Sandra Hybsier Niels-Peter Becker Magdalena Czuban Anne Tjonneland Malene Outzen Marie-Christine Boutron-Ruault Antoine Racine Nadia Bastide Tilman Kuhn Rudolf Kaaks Dimitrios Trichopoulos Antonia Trichopoulou Pagona Lagiou Salvatore Panico Petra H. Peeters Elisabete Weiderpass Guri Skeie Engeset Dagrun Maria-Dolores Chirlaque Maria-Jose Sanchez Eva Ardanaz Ingrid Ljuslinder Maria Wennberg Kathryn E. Bradbury Paolo Vineis Alessio Naccarati Domenico Palli Heiner Boeing Kim Overvad Miren Dorronsoro Paula Jakszyn Amanda J. Cross Jose Ramon Quiros Magdalena Stepien So Y. Kong Talita Duarte-Salles Elio Riboli John E. Hesketh 10779/rcsi.10791950.v1 https://repository.rcsi.com/articles/journal_contribution/Selenium_Status_is_Associated_with_Colorectal_Cancer_risk_in_the_European_Prospective_Investigation_of_Cancer_and_Nutrition_Cohort/10791950 <p>Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case-control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X-ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 µg/L and 4.3 mg/L in cases and 85.6 µg/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non-significant lower CRC risk (IRR = 0.92, 95%CI: 0.82-1.03 per 25 µg/L increase). However, sub-group analyses by sex showed a statistically significant association for women (Ptrend = 0.032; per 25 µg/L Se increase, IRR = 0.83, 95%CI: 0.70-0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (Ptrend = 0.009; per 0.806 mg/L increase, IRR = 0.89, 95%CI: 0.82-0.98) with the association more apparent in women (Ptrend = 0.004; IRR = 0.82, 95%CI: 0.72-0.94 per 0.806 mg/L increase) than men (Ptrend = 0.485; IRR = 0.98, 95%CI: 0.86-1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.</p> 2019-11-22 17:00:39 Selenium Selenium Status Colorectal Neoplasms Selenoprotein P Prospective Cohort Physiology Medical Physics