Selenium Status is Associated with Colorectal Cancer risk in the European Prospective Investigation of Cancer and Nutrition Cohort
David J. Hughes
Veronika Fedirko
Mazda Jenab
Lutz Schomburg
Catherine Meplan
Heinz Freisling
H B. Bueno-de-Mesquita
Sandra Hybsier
Niels-Peter Becker
Magdalena Czuban
Anne Tjonneland
Malene Outzen
Marie-Christine Boutron-Ruault
Antoine Racine
Nadia Bastide
Tilman Kuhn
Rudolf Kaaks
Dimitrios Trichopoulos
Antonia Trichopoulou
Pagona Lagiou
Salvatore Panico
Petra H. Peeters
Elisabete Weiderpass
Guri Skeie
Engeset Dagrun
Maria-Dolores Chirlaque
Maria-Jose Sanchez
Eva Ardanaz
Ingrid Ljuslinder
Maria Wennberg
Kathryn E. Bradbury
Paolo Vineis
Alessio Naccarati
Domenico Palli
Heiner Boeing
Kim Overvad
Miren Dorronsoro
Paula Jakszyn
Amanda J. Cross
Jose Ramon Quiros
Magdalena Stepien
So Y. Kong
Talita Duarte-Salles
Elio Riboli
John E. Hesketh
10779/rcsi.10791950.v1
https://repository.rcsi.com/articles/journal_contribution/Selenium_Status_is_Associated_with_Colorectal_Cancer_risk_in_the_European_Prospective_Investigation_of_Cancer_and_Nutrition_Cohort/10791950
<p>Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case-control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X-ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 µg/L and 4.3 mg/L in cases and 85.6 µg/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non-significant lower CRC risk (IRR = 0.92, 95%CI: 0.82-1.03 per 25 µg/L increase). However, sub-group analyses by sex showed a statistically significant association for women (Ptrend = 0.032; per 25 µg/L Se increase, IRR = 0.83, 95%CI: 0.70-0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (Ptrend = 0.009; per 0.806 mg/L increase, IRR = 0.89, 95%CI: 0.82-0.98) with the association more apparent in women (Ptrend = 0.004; IRR = 0.82, 95%CI: 0.72-0.94 per 0.806 mg/L increase) than men (Ptrend = 0.485; IRR = 0.98, 95%CI: 0.86-1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.</p>
2019-11-22 17:00:39
Selenium
Selenium Status
Colorectal Neoplasms
Selenoprotein P
Prospective Cohort
Physiology
Medical Physics