10779/rcsi.10797749.v1
John Hayden
John
Hayden
Ian Dawkins
Ian
Dawkins
Cormac Breatnach
Cormac
Breatnach
Finbarr P. Leacy
Finbarr P.
Leacy
June Foxton
June
Foxton
Martina Healy
Martina
Healy
Grainne Cousins
Grainne
Cousins
Paul Gallagher
Paul
Gallagher
Dermot R Doherty
Dermot R
Doherty
Effectiveness of α2agonists for sedation in paediatric critical care: study protocol for a retrospective cohort observational study.
Royal College of Surgeons in Ireland
2019
Adolescent
Adrenergic alpha-2 Receptor Agonists
Analgesics
Opioid
Anxiety
Child
Preschool
Clonidine
Dexmedetomidine
Humans
Infant
Intensive Care Units
Pediatric
Patient Comfort
Research Design
Respiration
Artificial
Retrospective Studies
Time Factors
Pharmaceutical Sciences
2019-11-22 17:20:58
Journal contribution
https://repository.rcsi.com/articles/journal_contribution/Effectiveness_of_2agonists_for_sedation_in_paediatric_critical_care_study_protocol_for_a_retrospective_cohort_observational_study_/10797749
<p><strong>INTRODUCTION:</strong> Mechanically ventilated children in paediatric intensive care units are commonly administered analgesics and sedative agents to minimise pain and distress and facilitate cooperation with medical interventions. Opioids and benzodiazepines are the most common analgesic and sedative agents but have safety concerns. The α</p>
<p><strong>METHODS AND ANALYSIS:</strong> We will conduct a retrospective cohort study in two Irish paediatric intensive care units using clinical information on patient characteristics, sedation scores and drug use. Eligible children admitted between January 2014 and June 2016 who were mechanically ventilated and received an opioid infusion will be included. Patients will be categorised into two exposure categories (received an α</p>
<p><strong>ETHICS AND DISSEMINATION:</strong> The study has been approved by the ethics committees of both hospitals. Dissemination will occur via local, national and international presentations for academic and healthcare audiences as well as through peer reviewed publications.</p>