10779/rcsi.10798070.v1
Ritesh M. Pabari
Ritesh M.
Pabari
Zebunnissa Ramtoola
Zebunnissa
Ramtoola
Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets.
Royal College of Surgeons in Ireland
2019
Administration
Oral
Anti-Inflammatory Agents
Non-Steroidal
Calcium Compounds
Chemistry
Pharmaceutical
Compressive Strength
Excipients
Factor Analysis
Statistical
Hardness
Hydrophobic and Hydrophilic Interactions
Ibuprofen
Kinetics
Linear Models
Mannitol
Models
Chemical
Particle Size
Porosity
Reproducibility of Results
Silicates
Solubility
Starch
Tablets
Technology
Pharmaceutical Sciences
2019-11-22 17:22:05
Journal contribution
https://repository.rcsi.com/articles/journal_contribution/Application_of_face_centred_central_composite_design_to_optimise_compression_force_and_tablet_diameter_for_the_formulation_of_mechanically_strong_and_fast_disintegrating_orodispersible_tablets_/10798070
<p>A two factor, three level (3(2)) face centred, central composite design (CCD) was applied to investigate the main and interaction effects of tablet diameter and compression force (CF) on hardness, disintegration time (DT) and porosity of mannitol based orodispersible tablets (ODTs). Tablet diameters of 10, 13 and 15 mm, and CF of 10, 15 and 20 kN were studied. Results of multiple linear regression analysis show that both the tablet diameter and CF influence tablet characteristics. A negative value of regression coefficient for tablet diameter showed an inverse relationship with hardness and DT. A positive value of regression coefficient for CF indicated an increase in hardness and DT with increasing CF as a result of the decrease in tablet porosity. Interestingly, at the larger tablet diameter of 15 mm, while hardness increased and porosity decreased with an increase in CF, the DT was resistant to change. The optimised combination was a tablet of 15 mm diameter compressed at 15 kN showing a rapid DT of 37.7s and high hardness of 71.4N. Using these parameters, ODTs containing ibuprofen showed no significant change in DT (ANOVA; p>0.05) irrespective of the hydrophobicity of the ibuprofen.</p>