Torri, Federica Stereoselective Synthesis of Enantiopure Abasic Nucleosides and 4-Nitroisoxazoles <p><em>Chapter 1</em></p> <p>A brief overview on organocatalysis and its application in 1,4-Michael type reactions.</p> <p><em>Chapter 2</em></p> <p>We have described a 1,6-Michael type addition of 4-pyridilacetonitrile to 4-nitro-5-styril-isoxazoles under PTC and bifunctional catalysis.</p> <p><em>Chapter 3</em></p> <p>We have reported a organocatalytic 1,4-conjugate addition of 1,3-dicarbonyl compounds (<em>i.e.</em> acetylacetone and malonate esters) to 4-nitro-5-styril-isoxazoles under bifunctional catalysis conditions.</p> <p><em>Chapter 4</em></p> <p>Herein we report organocatalytic aza-Michael additions to 4-nitro-5-styril-isoxazoles of different <em>N</em>-nucleophiles (<em>i.e.</em> indoline, <em>1H</em>-benzotriazole and <em>O</em>-benzylhydroxylamine) as Michael donors for the generation of building blocks with high potential synthetic utility.</p> <p><em>Chapter 5</em></p> <p>An enantioselective Michael-type conjugate addition of boronic acids, catalysed by chiral transition metal complexes, effective in the formation of <em>C-C</em> bonds, has been described using 4-nitro-5-styril-isoxazoles as Michael acceptors.</p> <p><em>Chapter 6</em></p> <p>The development of novel <em>C</em>-nucleosides analogues bearing functional groups able to complex divalent metal ions has been investigated. Here we describe the preparation of modified nucleosides, prepared from a cheap and readily available starting material (<em>i.e.</em> 2-deoxyribose).<em></em></p> Organocatalysis;Michael Type Addition;C-Nucleosides 2019-11-22
    https://repository.rcsi.com/articles/thesis/Stereoselective_Synthesis_of_Enantiopure_Abasic_Nucleosides_and_4-Nitroisoxazoles/10809596
10.25419/rcsi.10809596.v1