%0 Thesis %A Sherlock, Mark %D 2019 %T Clinical factors which influence the optimum management of patients with acromegaly %U https://repository.rcsi.com/articles/thesis/Clinical_factors_which_influence_the_optimum_management_of_patients_with_acromegaly/10814960 %R 10.25419/rcsi.10814960.v1 %2 https://repository.rcsi.com/ndownloader/files/19324613 %K Acromegaly %K Endocrine System Diseases %X
Acromegaly is a rare disabling disease characterised by excess growth hormone (GH) secretion and circulating insulin like growth factor-l (IGF-I) concentrations. In addition to significant morbidity, acromegaly is associated with increased mortality, which has been demonstrated in a number of retrospective studies with standardised mortality ratios (SMR) between 1.3 and 3 (comprising over 5,000 patients and 1,000 deaths).
Optimum management of patients with acromegaly requires appropriate investigation, treatment and defining targets for therapy that are associated with a reduction in overall morbidity and mortality in these patients. Due to the rare nature of this disease studies are often small and studies related to mortality are often multicentre (a limitation due to different growth hormone and IGF-I assays used in each centre).
With this in mind the West Midlands Acromegaly database was established in 1990 as a collaboration between 16 West Midland Endocrine centres and is centrally located at the Queen Elizabeth Hospital in Birmingham. The West Midlands region has an overall population of 5.7 million. To ensure optimum patient ascertainment, all patients with a diagnosis of acromegaly in each of the referral centres were flagged by physicians. Also, all patients with an elevated GH or IGF-I measurement in the Regional Endocrine laboratory at Selly Oak Hospital Birmingham were also flagged and their case notes assessed for a diagnosis of acromegaly. The Regional Endocrine laboratory at Selly Oak Hospital Birmingham is the regional centre for GH and IGF-I assays these assays, therefore all samples in the study were analysed here. Follow up biochemical and clinical data was recorded in the database. With this data the aims of this thesis were as follows: