10779/rcsi.10991345.v1 Harrison C. Daly Harrison C. Daly Gonzalo Sampedro Gonzalo Sampedro Corentin Bon Corentin Bon Dan Wu Dan Wu Ghazi Ismail Ghazi Ismail Ronan A. Cahill Ronan A. Cahill Donal F. O'Shea Donal F. O'Shea BF2-azadipyrromethene NIR-emissive fluorophores with research and clinical potential. Royal College of Surgeons in Ireland 2019 Aza Compounds Boron Compounds Colon Dose-Response Relationship Drug Fluorescent Dyes Humans Molecular Structure Porphobilinogen Spectroscopy Near-Infrared Structure-Activity Relationship 2019-11-23 11:49:26 Journal contribution https://repository.rcsi.com/articles/journal_contribution/BF2-azadipyrromethene_NIR-emissive_fluorophores_with_research_and_clinical_potential_/10991345 <p>The use of near-infrared fluorescence for in vivo research and intraoperative clinical imaging is rapidly expanding, with new applications being proposed and developed. While imaging hardware and software have significantly progressed in recent times, the molecular fluorescent agents remain a limiting factor. In this report, the design, synthesis, photophysical characterization and bio-medical imaging assessment of two new NIR-fluorophores based on the BF</p>