10779/rcsi.10991441.v1 Darren Griffith Darren Griffith Maria P. Morgan Maria P. Morgan Celine J. Marmion Celine J. Marmion A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity. Royal College of Surgeons in Ireland 2019 Antineoplastic Agents Cell Line Tumor Cell Proliferation DNA Drug Design Histone Deacetylase 1 Histone Deacetylase Inhibitors Humans Inhibitory Concentration 50 Molecular Structure Platinum Compounds 2019-11-23 11:50:01 Journal contribution https://repository.rcsi.com/articles/journal_contribution/A_novel_anti-cancer_bifunctional_platinum_drug_candidate_with_dual_DNA_binding_and_histone_deacetylase_inhibitory_activity_/10991441 <p>The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.</p>