10779/rcsi.10991441.v1
Darren Griffith
Darren
Griffith
Maria P. Morgan
Maria P.
Morgan
Celine J. Marmion
Celine J.
Marmion
A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity.
Royal College of Surgeons in Ireland
2019
Antineoplastic Agents
Cell Line
Tumor
Cell Proliferation
DNA
Drug Design
Histone Deacetylase 1
Histone Deacetylase Inhibitors
Humans
Inhibitory Concentration 50
Molecular Structure
Platinum Compounds
2019-11-23 11:50:01
Journal contribution
https://repository.rcsi.com/articles/journal_contribution/A_novel_anti-cancer_bifunctional_platinum_drug_candidate_with_dual_DNA_binding_and_histone_deacetylase_inhibitory_activity_/10991441
<p>The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.</p>