%0 Journal Article %A Griffith, Darren M. %A Krot, Krystyna %A Comiskey, Jedd %A Nolan, Kevin B. %A Marmion, Celine J. %D 2019 %T Monohydroxamic acids and bridging dihydroxamic acids as chelators to ruthenium(III) and as nitric oxide donors: syntheses, speciation studies and nitric oxide releasing investigations. %U https://repository.rcsi.com/articles/journal_contribution/Monohydroxamic_acids_and_bridging_dihydroxamic_acids_as_chelators_to_ruthenium_III_and_as_nitric_oxide_donors_syntheses_speciation_studies_and_nitric_oxide_releasing_investigations_/10991471 %2 https://repository.rcsi.com/ndownloader/files/19489088 %2 https://repository.rcsi.com/ndownloader/files/20020808 %K Bridged Compounds %K Hydroxamic Acids %K Molecular Structure %K Nitric Oxide %K Organometallic Compounds %K Ruthenium %K Spectrophotometry %K Ultraviolet %X

The synthesis and spectroscopic characterisation of novel mononuclear Ru(III)(edta)(hydroxamato) complexes of general formula [Ru(H2edta)(monoha)] (where monoha = 3- or 4-NH2, 2-, 3- or 4-C1 and 3-Me-phenylhydroxamato), as well as the first example of a Ru(III)-N-aryl aromatic hydroxamate, [Ru(H2edta)(N-Me-bha)].H2O (N-Me-bha = N-methylbenzohydroxamato) are reported. Three dinuclear Ru(III) complexes with bridging dihydroxamato ligands of general formula [{Ru(H2edta)}2(mu-diha)] where diha = 2,6-pyridinedihydroxamato and 1,3- or 1,4-benzodihydroxamato, the first of their kind with Ru(III), are also described. The speciation of all of these systems (with the exception of the Ru-1,4-benzodihydroxamic acid and Ru-N-methylbenzohydroxamic systems) in aqueous solution was investigated. We previously proposed that nitrosyl abstraction from hydroxamic acids by Ru(III) involves initial formation of Ru(III)-hydroxamates. Yet, until now, no data on the rate of nitric oxide (NO) release from hydroxamic acids has been published. We now describe a UV-VIS spectroscopic study, where we monitored the decrease in the ligand-to-metal charge-transfer band of a series of Ru(III)-monohydroxamates with time, with a view to gaining an insight into the NO-releasing properties of hydroxamic acids.

%I Royal College of Surgeons in Ireland