10779/rcsi.10991480.v1
Stephane Desgranges
Stephane
Desgranges
Florie Le Prieult
Florie
Le Prieult
Alan Daly
Alan
Daly
Marian Brennan
Marian
Brennan
Dilip K. Rai
Dilip K.
Rai
Anusha P. Subasinghage
Anusha P.
Subasinghage
Chandralal M. Hewage
Chandralal M.
Hewage
Sally-Ann Cryan
Sally-Ann
Cryan
Catherine M. Greene
Catherine M.
Greene
Noel G. McElvaney
Noel G.
McElvaney
Timothy P. Smyth
Timothy P.
Smyth
Deirdre Fitzgerald-Hughes
Deirdre
Fitzgerald-Hughes
Hilary Humphreys
Hilary
Humphreys
Marc Devocelle
Marc
Devocelle
In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.
Royal College of Surgeons in Ireland
2019
Cystic Fibrosis
Hemolysis
Humans
Leukocyte Elastase
Peptides
Pseudomonas aeruginosa
Staphylococcus aureus
2019-11-23 11:50:38
Journal contribution
https://repository.rcsi.com/articles/journal_contribution/In_vitro_activities_of_synthetic_host_defense_propeptides_processed_by_neutrophil_elastase_against_cystic_fibrosis_pathogens_/10991480
<p>The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.</p>