10779/rcsi.10991480.v1 Stephane Desgranges Stephane Desgranges Florie Le Prieult Florie Le Prieult Alan Daly Alan Daly Marian Brennan Marian Brennan Dilip K. Rai Dilip K. Rai Anusha P. Subasinghage Anusha P. Subasinghage Chandralal M. Hewage Chandralal M. Hewage Sally-Ann Cryan Sally-Ann Cryan Catherine M. Greene Catherine M. Greene Noel G. McElvaney Noel G. McElvaney Timothy P. Smyth Timothy P. Smyth Deirdre Fitzgerald-Hughes Deirdre Fitzgerald-Hughes Hilary Humphreys Hilary Humphreys Marc Devocelle Marc Devocelle In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens. Royal College of Surgeons in Ireland 2019 Cystic Fibrosis Hemolysis Humans Leukocyte Elastase Peptides Pseudomonas aeruginosa Staphylococcus aureus 2019-11-23 11:50:38 Journal contribution https://repository.rcsi.com/articles/journal_contribution/In_vitro_activities_of_synthetic_host_defense_propeptides_processed_by_neutrophil_elastase_against_cystic_fibrosis_pathogens_/10991480 <p>The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.</p>