Desgranges, Stephane Le Prieult, Florie Daly, Alan Brennan, Marian Rai, Dilip K. Subasinghage, Anusha P. Hewage, Chandralal M. Cryan, Sally-Ann Greene, Catherine M. McElvaney, Noel G. Smyth, Timothy P. Fitzgerald-Hughes, Deirdre Humphreys, Hilary Devocelle, Marc In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens. <p>The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.</p> Cystic Fibrosis;Hemolysis;Humans;Leukocyte Elastase;Peptides;Pseudomonas aeruginosa;Staphylococcus aureus 2019-11-23
    https://repository.rcsi.com/articles/journal_contribution/In_vitro_activities_of_synthetic_host_defense_propeptides_processed_by_neutrophil_elastase_against_cystic_fibrosis_pathogens_/10991480