10779/rcsi.10991486.v1
Aoife M. McKeon
Aoife M.
McKeon
Alan Egan
Alan
Egan
Jay Chandanshive
Jay
Chandanshive
Helena McMahon
Helena
McMahon
Darren M. Griffith
Darren M.
Griffith
Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells.
Royal College of Surgeons in Ireland
2019
Chou-Talalay method
cancer
combination study
heat shock protein 70
pifithrin-μ
platinum
synthesis.
2019-11-23 11:50:48
Journal contribution
https://repository.rcsi.com/articles/journal_contribution/Novel_Improved_Synthesis_of_HSP70_Inhibitor_Pifithrin-_In_Vitro_Synergy_Quantification_of_Pifithrin-_Combined_with_Pt_Drugs_in_Prostate_and_Colorectal_Cancer_Cells_/10991486
<p>We describe a novel improved approach to the synthesis of the important and well-known heat shock protein 70 inhibitor (HSP70), pifithrin-μ, with corresponding and previously unreported characterisation. The first example of a combination study comprising HSP70 inhibitor pifithrin-μ and cisplatin or oxaliplatin is reported. We have determined, using the Chou-Talalay method, (i) moderate synergistic and synergistic effects in co-treating PC-3 prostate cancer cells with pifithrin-μ and cisplatin and (ii) significant synergistic effects including strong synergism in cotreating HT29 colorectal cancer cells with oxaliplatin and pifithrin-μ.</p>