Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y1 Receptor in Experimental Epilepsy
Mariana Alves
Laura De Diego Garcia
Giorgia Conte
Eva M. Jimenez-Mateos
Beatrice D’Orsi
Amaya Sanz Rodriguez
Jochen Prehn
David Henshall
Tobias Engel
10779/rcsi.12628241.v1
https://repository.rcsi.com/articles/journal_contribution/Context-Specific_Switch_from_Anti-_to_Pro-epileptogenic_Function_of_the_P2Y1_Receptor_in_Experimental_Epilepsy/12628241
This is the first study to fully characterize the contribution of a metabotropic purinergic P2Y receptor during acute seizures and
epilepsy. The findings suggest that targeting P2Y1 may offer a potential novel treatment strategy for drug-refractory status
epilepticus and epilepsy. Our data demonstrate a context-specific role of P2Y1 activation during seizures, switching from a
proconvulsiveto an anticonvulsive role depending on physiopathological context. Thus, our study provides a possible explanation
for seemingly conflicting results obtained between studies of different brain diseases where P2Y1 targeting has been proposed as
a potential treatment strategy and highlights that the timing of pharmacological interventions is of critical importance to the
understanding of how receptors contribute to the generation of seizures and the development of epilepsy.
2020-07-10 14:14:15
Animal Model
p2y1
Purinergic Signaling
Status epilepticus
Neuroscience