Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y1 Receptor in Experimental Epilepsy Mariana Alves Laura De Diego Garcia Giorgia Conte Eva M. Jimenez-Mateos Beatrice D’Orsi Amaya Sanz Rodriguez Jochen Prehn David Henshall Tobias Engel 10779/rcsi.12628241.v1 https://repository.rcsi.com/articles/journal_contribution/Context-Specific_Switch_from_Anti-_to_Pro-epileptogenic_Function_of_the_P2Y1_Receptor_in_Experimental_Epilepsy/12628241 This is the first study to fully characterize the contribution of a metabotropic purinergic P2Y receptor during acute seizures and epilepsy. The findings suggest that targeting P2Y1 may offer a potential novel treatment strategy for drug-refractory status epilepticus and epilepsy. Our data demonstrate a context-specific role of P2Y1 activation during seizures, switching from a proconvulsiveto an anticonvulsive role depending on physiopathological context. Thus, our study provides a possible explanation for seemingly conflicting results obtained between studies of different brain diseases where P2Y1 targeting has been proposed as a potential treatment strategy and highlights that the timing of pharmacological interventions is of critical importance to the understanding of how receptors contribute to the generation of seizures and the development of epilepsy. 2020-07-10 14:14:15 Animal Model p2y1 Purinergic Signaling Status epilepticus Neuroscience