Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2.

Early, James O.; Menon, Deepthi; Wyse, Cathy A.; Cervantes-Silva, Mariana P.; Zaslona, Zbigniew; Carroll, Richard G.; Palsson-McDermott, Eva M.; Angiari, Stefano; Ryan, Dylan G.; Corcoran, Sarah E.; Timmons, George; Geiger, Sarah S.; Fitzpatrick, Darren J.; O'Connell, Daniel; Xavier, Ramnik J.; Hokamp, Karsten; O'Neill, Luke AJ; Curtis, Anne M.

Circadian clock protein BMAL1 regulates IL-1? in macrophages via.pdf (2.49 MB)

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2.

Version 2 2022-01-19, 12:16

Version 1 2019-11-22, 16:17

journal contribution

posted on 2019-11-22, 16:17 authored by James O. Early, Deepthi Menon, Cathy A. Wyse, Mariana P. Cervantes-Silva, Zbigniew Zaslona, Richard G. Carroll, Eva M. Palsson-McDermott, Stefano Angiari, Dylan G. Ryan, Sarah E. Corcoran, George Timmons, Sarah S. Geiger, Darren J. Fitzpatrick, Daniel O'Connell, Ramnik J. Xavier, Karsten Hokamp, Luke AJ O'Neill, Anne M. Curtis

A variety of innate immune responses and functions are dependent on time of day, and many inflammatory conditions are associated with dysfunctional molecular clocks within immune cells. However, the functional importance of these innate immune clocks has yet to be fully characterized. NRF2 plays a critical role in the innate immune system, limiting inflammation via reactive oxygen species (ROS) suppression and direct repression of the proinflammatory cytokines, IL-1β and IL-6. Here we reveal that the core molecular clock protein, BMAL1, controls the mRNA expression of

Funding

Science Foundation Ireland (SFI) Starting Investigator Research Award 13/SIRG/2130. SFI Career Development Award 17/CDA/4688. Wellcome Trust Metabolic Grant 205455.

History

Comments

The original article is available at http://www.pnas.org

Published Citation

Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, Timmons G, Geiger SS, Fitzpatrick DJ, O'Connell D4, Xavier RJ, Hokamp K, O'Neill LAJ, Curtis AM. Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(36):E8460-E8468.