Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.

Babovic, Daniela; O'Tuathaigh, Colm M.; O'Sullivan, Gerard J.; Clifford, Jeremiah J.; Tighe, Orna; Croke, David T.; Karayiorgou, Maria; Gogos, Joseph A.; Cotter, David; Waddington, John L.

Exploratory and habituation phenotype of heterozygous and homozyg.pdf (394.97 kB)

Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.

Version 2 2022-03-31, 08:46

Version 1 2019-11-22, 16:25

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posted on 2019-11-22, 16:25 authored by Daniela Babovic, Colm M. O'Tuathaigh, Gerard J. O'Sullivan, Jeremiah J. Clifford, Orna Tighe, David T. Croke, Maria Karayiorgou, Joseph A. Gogos, David Cotter, John L. Waddington

Catechol-O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an ethologically based approach, the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing. Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1.

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This article is available at http://www.sciencedirect.com/science/journal/01664328.

Published Citation

Babovic D, O'Tuathaigh CM, O'Sullivan GJ, Clifford JJ, Tighe O, Croke DT, Karayiorgou M, Gogos JA, Cotter D, Waddington JL. Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice. Behavioural Brain Research 2007;183(2):236-9.