Hyperthermia-induced drug delivery from thermosensitive liposomes.pdf (961.33 kB)
Hyperthermia-induced drug delivery from thermosensitive liposomes encapsulated in an injectable hydrogel for local chemotherapy.
Version 2 2022-04-07, 15:20
Version 1 2019-11-22, 15:12
journal contribution
posted on 2019-11-22, 15:12 authored by Adolfo López-Noriega, Conn L. Hastings, Burcin Ozbakir, Kathleen E. O'Donnell, Fergal O'Brien, Gert Storm, Wim E. Hennink, Garry P. Duffy, Eduardo Ruiz-HernándezA novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy.