Immune inflammatory and infectious consequences of estrogen in w.pdf (177.69 kB)
Immune, inflammatory and infectious consequences of estrogen in women with cystic fibrosis.
Version 2 2022-03-31, 13:51
Version 1 2019-11-22, 16:28
journal contribution
posted on 2019-11-22, 16:28 authored by Sanjay H. Chotirmall, Catherine M. Greene, Noel G. McElvaneyCystic fibrosis (CF), a multi-system genetic disease with predominantly pulmonary manifestations, occurs due to defective chloride secretion at epithelial surfaces. The consequential sodium hyper-absorption leads to mucus hypersecretion, compromised mucociliary clearance and pathogenic colonization by, for instance, Staphylococcus aureus and/or Pseudomonas aeruginosa. This sequence of events leads to recurrent infection and persistent chronic neutrophilic inflammation causing airway damage, irreversible bronchiectasis, respiratory failure and death.