In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.

Desgranges, Stephane; Le Prieult, Florie; Daly, Alan; Brennan, Marian; Rai, Dilip K.; Subasinghage, Anusha P.; Hewage, Chandralal M.; Cryan, Sally-Ann; Greene, Catherine M.; McElvaney, Noel G.; Smyth, Timothy P.; Fitzgerald-Hughes, Deirdre; Humphreys, Hilary; Devocelle, Marc

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In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.

Version 2 2021-04-12, 15:39

Version 1 2019-11-23, 11:50

journal contribution

posted on 2019-11-23, 11:50 authored by Stephane Desgranges, Florie Le Prieult, Alan Daly, Marian Brennan, Dilip K. Rai, Anusha P. Subasinghage, Chandralal M. Hewage, Sally-Ann Cryan, Catherine M. Greene, Noel G. McElvaney, Timothy P. Smyth, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Marc Devocelle

The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.

Funding

This publication has emanated from research conducted with the financial support of Science Foundation Ireland (05/RFP/CHE0063 and 06/RFP/CHO024/EC07 to M.D. and 06/RFP/CHO006 to C.M.H.)

History

Comments

The original article is available at http://aac.asm.org/content/55/5/2487.full.pdf+html

Published Citation

Desgranges S, Le Prieult F, Daly A, Lydon J, Brennan M, Rai DK, Subasinghage AP, Hewage CM, Cryan SA, Greene C, McElvaney NG, Smyth TP, Fitzgerald-Hughes D, Humphreys H, Devocelle M. In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens. Antimicrobial Agents and Chemotherapy 2011;55(5):2487-9