Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential.

Matsiko, Amos; Levingstone, Tanya J.; Gleeson, John P.; O'Brien, Fergal

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Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential.

Version 2 2021-09-02, 16:14

Version 1 2019-11-22, 15:12

journal contribution

posted on 2019-11-22, 15:12 authored by Amos Matsiko, Tanya J. Levingstone, John P. Gleeson, Fergal O'Brien

Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen-hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.

Funding

Enterprise Ireland, Commercialization Fund Technology

History

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The original article is available at onlinelibrary.wiley.com

Published Citation

Matsiko A, Levingstone TJ, Gleeson JP, O'Brien FJ. Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential. Advanced Healthcare Materials. 2015;4(8):1175-9.