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MicroRNA Expression in Cystic Fibrosis Airway Epithelium.

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journal contribution
posted on 22.11.2019 by Catherine M. Greene

MicroRNAs (miRs) have emerged as major regulators of the protein content of a cell. In the most part, miRs negatively regulate target mRNA expression, with sets of miRs predicted to regulate certain signaling pathways. The miR expression profile of endobronchial brushings is altered in people with cystic fibrosis (CF) compared to those without CF. How this impacts on CF has important implications for our growing understanding of the pathophysiology of CF lung disease and the development of new therapeutics to treat its pulmonary manifestations. Herein we discuss the potential consequences of altered miR expression in CF airway epithelium particularly with respect to cystic fibrosis transmembrane conductance regulator (CFTR) expression, innate immunity and toll-like receptor signalling and explore how best to exploit these changes for therapeutic benefit.

Funding

Health Research Board (Grant No. PhD/2007/11). Science Foundation Ireland (Grant No. 12/TIDA/B2265).

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The original article is available at www.mdpi.com

Published Citation

Greene CM. MicroRNA Expression in Cystic Fibrosis Airway Epithelium. Biomolecules. 2013;3(1):157-67.

Publication Date

11/02/2013

Publisher

MDPI

PubMed ID

24970162

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