New Research on the Importance of Cystic Fibrosis Transmembrane C.pdf (3.97 MB)
New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity
Version 2 2022-03-23, 16:49
Version 1 2019-11-22, 16:35
chapter
posted on 2019-11-22, 16:35 authored by Michelle M. White, Fatma Gargoum, Niall Browne, Killian Hurley, Noel G. McElvaney, Emer P. ReevesDespite tremendous recent advances in our understanding of the molecular and cellular basis of cystic fibrosis (CF), there remains a paradox of why recruited neutrophils fail to eradicate bacterial infections in the airways of individuals with CF. The focus of this chapter is on new research authenticating the CF neutrophil as a key player in disease pathogenesis. Studies specifying intrinsic abnormalities due to a lack of cystic fibrosis transmembrane conductance regulator (CFTR) function, along with reports indicating reprogrammed cell activity secondary to chronic bacterial infection and inflammation, will be discussed.