Novel Improved Synthesis of HSP70 Inhibitor Pifithrin-?. In Vitr.pdf (1.39 MB)
0/0

Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells.

Download (1.39 MB)
journal contribution
posted on 23.11.2019 by Aoife M. McKeon, Alan Egan, Jay Chandanshive, Helena McMahon, Darren M. Griffith

We describe a novel improved approach to the synthesis of the important and well-known heat shock protein 70 inhibitor (HSP70), pifithrin-μ, with corresponding and previously unreported characterisation. The first example of a combination study comprising HSP70 inhibitor pifithrin-μ and cisplatin or oxaliplatin is reported. We have determined, using the Chou-Talalay method, (i) moderate synergistic and synergistic effects in co-treating PC-3 prostate cancer cells with pifithrin-μ and cisplatin and (ii) significant synergistic effects including strong synergism in cotreating HT29 colorectal cancer cells with oxaliplatin and pifithrin-μ.

Funding

Science Foundation Ireland. Institute of Technology, Tralee.

History

Comments

The original article is available at http://www.mdpi.com

Published Citation

McKeon AM, Egan A, Chandanshive J, McMahon H, Griffith DM. Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells. Molecules. 2016;21(7). pii: E949

Publication Date

21/07/2016

Publisher

MDPI AG

PubMed ID

27455212

Exports

Logo branding

Categories

Exports