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The revolving door between hospital and community: extended-spectrum beta-lactamase-producing Escherichia coli in Dublin.

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posted on 22.11.2019 by Liam Burke, Hilary Humphreys, Deirdre Fitzgerald-Hughes

BACKGROUND: Escherichia coli that produce extended-spectrum beta-lactamases (ESBLs) are an increasing cause of healthcare-associated infection, and community healthcare facilities may be a reservoir for important epidemic clones.

AIM: To characterize retrospectively and investigate the epidemiology of ESBL-producing E. coli collected in a Dublin hospital, during 2009 and 2010, and to investigate the dissemination of specific clones within hospital and community healthcare facilities.

METHODS: Pulsed-field gel electrophoresis (PFGE) was used to determine the genetic relatedness of 100 ESBL-producing E. coli isolates. Phylogenetic groups were determined and the O25b-ST131 clone identified in the collection. The genetic data were correlated with antimicrobial susceptibility, clinical and demographic data to explore the epidemiology of specific clones.

FINDINGS: Phylogenetic groups B2 (62%) and D (18%) were the most common and were associated with non-urinary isolates (P

CONCLUSIONS: E. coli O25b-ST131 is largely responsible for ESBL-producing E. coli in LTCFs in Dublin. The distribution of ESBL-producing E. coli in our hospital and community highlights a 'revolving door' through which these resistant bacteria spread and disseminate.

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This article is also available at http://www.journalofhospitalinfection.com/ or http://www.sciencedirect.com/science/article/pii/S0195670112001314

Published Citation

Burke L, Fitzgerald-Hughes D, Humphreys H. The revolving door between hospital and community: extended-spectrum beta-lactamase-producing Escherichia coli in Dublin. Journal of Hospital Infection. 2012;81(3):192-8.

Publication Date

01/07/2012

PubMed ID

22658893

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