Trial of feasibility and acceptability of routine low-dose aspirin versus Early Screening Test indicated aspirin for pre-eclampsia prevention (TEST study): a multicentre randomised controlled trial.

Mone, Fionnuala; Mulcahy, Cecilia; McParland, Peter; Breathnach, Fionnuala; Downey, Paul; McCormack, Dorothy; Culliton, Marie; Stanton, Alice V.; Cody, Fiona; Morrison, John J.; Daly, Sean; Higgins, John; Cotter, Amanda; Hunter, Alyson; Tully, Elizabeth C.; Dicker, Patrick; Alfirevic, Zarko; Malone, Fergal; McAuliffe, Fionnuala M.

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Trial of feasibility and acceptability of routine low-dose aspirin versus Early Screening Test indicated aspirin for pre-eclampsia prevention (TEST study): a multicentre randomised controlled trial.

Version 2 2022-01-19, 09:44

Version 1 2019-11-22, 16:44

journal contribution

posted on 2019-11-22, 16:44 authored by Fionnuala Mone, Cecilia Mulcahy, Peter McParland, Fionnuala Breathnach, Paul Downey, Dorothy McCormack, Marie Culliton, Alice V. Stanton, Fiona Cody, John J. Morrison, Sean Daly, John Higgins, Amanda Cotter, Alyson Hunter, Elizabeth C. Tully, Patrick Dicker, Zarko Alfirevic, Fergal Malone, Fionnuala M. McAuliffe

OBJECTIVE: Evaluate the feasibility and acceptability of routine aspirin in low-risk women, compared with screening-test indicated aspirin for the prevention of pre-eclampsia and fetal growth restriction.

DESIGN: Multicentre open-label feasibility randomised controlled trial.

SETTING: Two tertiary maternity hospitals in Dublin, Ireland.

PARTICIPANTS: 546 low-risk nulliparous women completed the study.

INTERVENTIONS: Women underwent computerised randomisation to: Group 1-routine aspirin 75 mg from 11 until 36 weeks; Group 2-no aspirin and; Group 3-aspirin based on the Fetal Medicine Foundation screening test. PRIMARY AND SECONDARY OUTCOME MEASURES: (1) Proportion agreeing to participate; (2) compliance with protocol; (3) proportion where first trimester uterine artery Doppler was obtainable and; (4) time taken to issue a screening result. Secondary outcomes included rates of pre-eclampsia and small-for-gestational-age fetuses.

RESULTS: 546 were included in the routine aspirin (n=179), no aspirin (n=183) and screen and treat (n=184) groups. 546 of 1054 were approached (51.8%) and enrolled. Average aspirin adherence was 90%. The uterine artery Doppler was obtained in 98.4% (181/184) and the average time to obtain a screening result was 7.6 (0-26) days. Of those taking aspirin, vaginal spotting was greater; n=29 (15.1%), non-aspirin n=28 (7.9%), OR 2.1 (95% CI 1.2 to 3.6). Postpartum haemorrhage >500 mL was also greater; aspirin n=26 (13.5%), no aspirin n=20 (5.6%), OR 2.6 (95% CI 1.4 to 4.8).

CONCLUSION: Low-risk nulliparous women are open to taking aspirin in pregnancy and had high levels of adherence. Aspirin use was associated with greater rates of vaginal bleeding. An appropriately powered randomised controlled trial is now required to address the efficacy and safety of universal low-dose aspirin in low-risk pregnancy compared with a screening approach.

TRIAL REGISTRATION NUMBER: ISRCTN (15191778); Post-results.

Funding

Perinatal Ireland HRB and HRB Mother and Baby Clinical Trials Network.

History

Comments

The original article is available at bmjopen.bmj.com

Published Citation

Mone F, Mulcahy C, McParland P, Breathnach F, Downey P, McCormack D, Culliton M, Stanton A, Cody F, Morrison JJ, Daly S, Higgins J, Cotter A, Hunter A, Tully EC, Dicker P, Alfirevic Z, Malone FD, McAuliffe FM. Trial of feasibility and acceptability of routine low-dose aspirin versus Early Screening Test indicated aspirin for pre-eclampsia prevention (TEST study): a multicentre randomised controlled trial. BMJ Open. 2018;8(7):e022056.