New Research on the Importance of Cystic Fibrosis Transmembrane C.pdf (3.97 MB)

New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity

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posted on 22.11.2019, 16:35 by Michelle M. White, Fatma Gargoum, Niall Browne, Killian Hurley, Noel G. McElvaney, Emer P. Reeves

Despite tremendous recent advances in our understanding of the molecular and cellular basis of cystic fibrosis (CF), there remains a paradox of why recruited neutrophils fail to eradicate bacterial infections in the airways of individuals with CF. The focus of this chapter is on new research authenticating the CF neutrophil as a key player in disease pathogenesis. Studies specifying intrinsic abnormalities due to a lack of cystic fibrosis transmembrane conductance regulator (CFTR) function, along with reports indicating reprogrammed cell activity secondary to chronic bacterial infection and inflammation, will be discussed.

Funding

U.S. Cystic Fibrosis Foundation and Science Foundation Ireland under the Research Frontiers Programme (11/RFP/BMT/3094) and the Program for Research in Third Level Institutes administered by the Higher Education Authority in Ireland

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This chapter is available from InTech at http://www.intechopen.com/books

Published Citation

White MM, Gargoum F, Browne N, Hurley K, McElvaney NG and Reeves EP. New Research on the Importance of Cystic Fibrosis Transmembrane Conductance Regulator Function for Optimal Neutrophil Activity. In: Wat D (ed) Cystic Fibrosis in the Light of New Research. Rijeka, Croatia: InTech; 2015. p249-278

Publication Date

01/08/2015

Publisher

InTech

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