Royal College of Surgeons in Ireland
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Post-Translational Modification of MR Activity

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posted on 2019-11-22, 16:40 authored by Diego Alvarez de la Rosa, Natalia Serrano-Morillas

The mineralocorticoid receptor (MR) is a ligand-activated transcription factor that transduces the effects of aldosterone and glucocorticoids in a tissue- and cell type-specific ways. Differential regulation of MR by post-translational modifications (PTMs) has been proposed to play a key role in modulating its function. In addition, modifications of other proteins that physically or functionally interact with MR add an additional layer of regulation to aldosterone or glucocorticoid signaling. In this chapter, we will summarize the main post-translational modifications of MR described so far, discussing their possible implications in the physiological and pathological roles of the receptor. We will also discuss post-translational modulation of other proteins impacting MR function such as heat shock protein 90 or 11ß-hydroxysteroid dehydrogenase type 2.



The original book chapter is available at Editor: Prof Brian Harvey, Molecular Medicine, RCSI Part of the ‘Aldosterone-Mineralocorticoid Receptor: Cell Biology to Translational Medicine’ collection:

Published Citation

Alvarez de la Rosa D, Serrano-Morillas N. Post-Translational Modification of MR Activity In: Harvey B, Jaisser F, editors. Aldosterone-Mineralocorticoid Receptor - Cell Biology to Translational Medicine: InTechOpen; 2019.

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  • Molecular Medicine