Royal College of Surgeons in Ireland
Respiratory drug vaccine delivery using nanoparticles.pdf (1009.11 kB)

Respiratory drug/vaccine delivery using nanoparticles

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posted on 2022-08-04, 16:21 authored by Joanne M Ramsey, Alice McCloskey, Rachel Gaul, Elena F Fernandez, Louise Sweeney, Catherine GreeneCatherine Greene, Ronan MacLoughlinRonan MacLoughlin, Sally-Ann CryanSally-Ann Cryan
Respiratory diseases account for a very significant portion of worldwide morbidity and mortality but to-date only a limited number of therapeutics are available for direct delivery via inhalation. Nanotechnology offers a range of potential benefits to facilitate the targeted delivery/co-delivery of existing therapeutic agents and to support the delivery of more advanced biotherapeutics e.g. proteins, gene medicines. The clinical and commercial translation of inhalable nanomedicines is not trivial and presents significant formulation, manufacturing, assessment and regulatory challenges. Herein, we explore the range of respiratory diseases being targeted using nanoparticle-based delivery systems for therapeutics and vaccines, the composition and manufacture of these nanoparticles, their integration into relevant inhaler devices, the methods being used to characterize these nanoparticles in vitro and in vivo and the regulatory requirements governing inhaled nanomedicines.





The original chapter is available at

Published Citation

Ramsey, JM. et al. Respiratory Drug/Vaccine Delivery Using Nanoparticles. In: Muttil, P., Kunda, N. (eds) Mucosal Delivery of Drugs and Biologics in Nanoparticles. AAPS Advances in the Pharmaceutical Sciences Series. 2020. vol 41. Springer, Cham.



Publication Date

19 March 2020


Springer International Publishing


  • Amber (Advanced Material & Bioengineering Research) Centre
  • Beaumont Hospital
  • Clinical Microbiology
  • CURAM Centre for Research in Medical Devices
  • School of Pharmacy and Biomolecular Sciences
  • Tissue Engineering Research Group (TERG)
  • Anatomy and Regenerative Medicine

Research Area

  • Chemistry and Pharmaceutical Sciences
  • Immunity, Infection and Inflammation
  • Respiratory Medicine
  • Biomaterials and Regenerative Medicine