A Method to Calculate Adherence to Inhaled Therapy That Reflects.pdf (1.13 MB)

A Method to Calculate Adherence to Inhaled Therapy That Reflects the Changes in Clinical Features of Asthma.

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posted on 22.11.2019, 16:36 by Imran Sulaiman, Jansen Seheult, Elaine MacHale, Fiona Boland, Susan M O'Dwyer, Viliam Rapcan, Shona D'Arcy, Breda Cushen, Matshediso Mokoka, Isabelle Killane, Sheila A. Ryder, Richard B. Reilly, Richard W. Costello

Rationale Currently studies on adherence to inhaled medications report Average Adherence over time. This measure does not account for variations in the interval between doses nor for errors in inhaler use. Objectives We investigated whether adherence calculated as a single Area Under the concentration-time Curve (AUC) measure, incorporating the interval between doses and inhaler technique, was more reflective of patient outcomes than current methods of assessing adherence. Methods We attached a digital audio device (INCATM) to a dry powder inhaler. This recorded when the inhaler was used and analysis of the audio data indicated if the inhaler had been used correctly. These aspects of inhaler use were combined to calculate adherence over time, as an AUC measure. Over a 3 month period a cohort of asthma patients were studied. Adherence to a twice-daily inhaler preventer therapy using this device and clinical measures were assessed. Measurements and Results Recordings from 239 patients with severe asthma were analysed. Average Adherence, based on the dose counter was 84.4%, whereas the ratio of expected to observed accumulated AUC, Actual Adherence, was 61.8% (p

Funding

Health Research Board of Ireland. Royal College of Surgeons in Ireland.

History

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Originally Published in: Sulaiman I, Seheult J, MacHale E, Boland F, O'Dwyer SM, Rapcan V, D'Arcy S, Cushen B, Mokoka M, Killane I, Ryder SA, Reilly RB, Costello RW. A Method to Calculate Adherence to Inhaled Therapy That Reflects the Changes in Clinical Features of Asthma. Anns of the American Thoracic Society. 2016; 13(11):1894-1903. DOI: 10.1513/AnnalsATS.201603-222OC. Copyright © 2015 by the American Thoracic Society. The final publication is available at http://www.atsjournals.org/doi/pdf/10.1513/AnnalsATS.201603-222OC

Published Citation

Sulaiman I, Seheult J, MacHale E, Boland F, O'Dwyer SM, Rapcan V, D'Arcy S, Cushen B, Mokoka M, Killane I, Ryder SA, Reilly RB, Costello RW. A Method to Calculate Adherence to Inhaled Therapy That Reflects the Changes in Clinical Features of Asthma. Annals of the American Thoracic Society. 2016;13(11):1894-1903.

Publication Date

28/07/2016

Publisher

American Thoracic Society

PubMed ID

27467125

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