An endochondral ossification approach to early-stage bone repair:.pdf (554.77 kB)

An endochondral ossification approach to early-stage bone repair: Use of tissue-engineered hypertrophic cartilage constructs as primordial templates for weight-bearing bone repair.

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posted on 22.11.2019, 15:04 by Amos Matsiko, Emmet Thompson, Cai Lloyd-Griffith, Gráinne M. Cunniffe, Tatiana Vinardell, John Patrick Gleeson, Daniel J. Kelly, Fergal O'Brien

Mimicking endochondral ossification to engineer constructs offers a novel solution to overcoming the problems associated with poor vascularisation in bone repair. This can be achieved by harnessing the angiogenic potency of hypertrophic cartilage. In this study, we demonstrate that tissue-engineered hypertrophically-primed cartilage constructs can be developed from collagen-based scaffolds cultured with mesenchymal stem cells. These constructs were subsequently implanted into femoral defects in rats. It was evident that the constructs could support enhanced early-stage healing at 4 weeks of these weight-bearing femoral bone defects compared to untreated defects.

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Funding

Health Research Board of Ireland (Grant No. HRA_POR/2011/27) European Research Council (ERC Grant Agreement No. 239685).

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This is the peer reviewed version of the following article: Matsiko A, Thompson EM, Lloyd-Griffith C, Cunniffe GM, Vinardell T, Gleeson JP, Kelly DJ, O'Brien FJ. An endochondral ossification approach to early-stage bone repair: Use of tissue-engineered hypertrophic cartilage constructs as primordial templates for weight-bearing bone repair. Journal of Tissue Engineering and Regenerative Medicine. 2018. which has been published in final form at DOI:10.1002/term.2638. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Published Citation

Matsiko A, Thompson EM, Lloyd-Griffith C, Cunniffe GM, Vinardell T, Gleeson JP, Kelly DJ, O'Brien FJ. An endochondral ossification approach to early-stage bone repair: Use of tissue-engineered hypertrophic cartilage constructs as primordial templates for weight-bearing bone repair. Journal of Tissue Engineering and Regenerative Medicine. 2018

Publication Date

11/01/2018

Publisher

Wiley

PubMed ID

29327428

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