Anti-apoptotic BCL-2 family proteins in acute neural injury..pdf (330.56 kB)
0/0

Anti-apoptotic BCL-2 family proteins in acute neural injury.

Download (330.56 kB)
journal contribution
posted on 22.11.2019 by Ujval Anilkumar, Jochen HM Prehn

Cells under stress activate cell survival and cell death signaling pathways. Cell death signaling frequently converges on mitochondria, a process that is controlled by the activities of pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) proteins. In this review, we summarize current knowledge on the control of neuronal survival, development and injury by anti-apoptotic BCL-2 family proteins. We discuss overlapping and differential effects of the individual family members BCL-2, BCL-extra long (BCL-XL), myeloid cell leukemia 1 (MCL-1), and BCL2-like 2 (BCL-W) in the control of survival during development and pathophysiological processes such as trophic factor withdrawal, ischemic injury, excitotoxicity, oxidative stress and energy stress. Finally we discuss recent evidence that several anti-apoptotic BCL-2 proteins influence mitochondrial bioenergetics and control neuronal Ca(2+) homeostasis independent of their classical role in cell death signaling.

Funding

This work was funded by Science Foundation Ireland (13/IA/1881 and 08/IN1/B1949) and the European Union FP7 Marie Curie IAPP program (OXY-SENSE; Contract 230641) to Jochen H.M. Prehn.

History

Comments

This article is also available at http://journal.frontiersin.org/article/10.3389/fncel.2014.00281/abstract

Published Citation

Anilkumar U, Prehn JHM. Anti-apoptotic BCL-2 family proteins in acute neural injury. Frontiers in Cellular Neuroscience. 2014;8:281

Publication Date

01/01/2014

PubMed ID

25324720

Exports

Logo branding

Exports