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Correlates of Vitamin D in Psychotic Disorders: A comprehensive Systematic Review

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posted on 22.11.2019, 17:15 by James Adamson, John Lally, Fiona Gaughran, Amir Krivoy, Lauren Allen, Brendon Stubbs

People with psychosis have high prevalence of low vitamin D levels but the correlates and relevance of this deficiency are unclear. A systematic search of major databases from inception to 03/2016 was undertaken investigating correlates of vitamin D in people with psychosis. Data was summarised with a best evidence synthesis. Across 23 included studies (n=1,770 psychosis, n= 8,171 controls) a mean difference in vitamin D levels between both groups of −11.14 ng/ml ±0.59 was found. 53 unique correlations between vitamin D and outcomes in people with psychosis were identified. The evidence base was broadly equivocal although season of blood sampling (67% of studies found a positive correlation with warmer seasons) and parathyroid hormone (100% of studies found a negative correlation) were associated with vitamin D levels. The most commonly non-correlated variables were: BMI (83% found no correlation), age (73%), gender (86%), smoking (100%), duration of illness (100%) and general assessment of functioning score (100%). In conclusion, whilst many unique correlates have been investigated, there is weak and inconclusive evidence regarding the consistency and meaning of the correlates of vitamin D levels in people with psychosis. Future longitudinal studies should consider the correlates of vitamin D in people with psychosis

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Published Citation

Adamson J, Lally J, Gaughran F, Kirvoy A, Allen L, Stubbs B. Correlates of Vitamin D in Psychotic Disorders: A comprehensive Systematic Review. Psychiatry Research. 2017; 249:78-85.

Publication Date

01/01/2017

Publisher

Psychiatry Research

PubMed ID

28081455

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