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posted on 22.11.2019by Cathal J. Kearney, Christopher R. Lucas, Fergal J. O'Brien, Carlos E. Castro
DNA origami is a DNA-based nanotechnology that utilizes programmed combinations of short complementary oligonucleotides to fold a large single strand of DNA into precise 2D and 3D shapes. The exquisite nanoscale shape control of this inherently biocompatible material is combined with the potential to spatially address the origami structures with diverse cargoes including drugs, antibodies, nucleic acid sequences, small molecules, and inorganic particles. This programmable flexibility enables the fabrication of precise nanoscale devices that have already shown great potential for biomedical applications such as: drug delivery, biosensing, and synthetic nanopore formation. Here, the advances in the DNA-origami field since its inception several years ago are reviewed with a focus on how these DNA-nanodevices can be designed to interact with cells to direct or probe their behavior.
RCSI’s Ofﬁce of Research and Innovation Seed Fund Award (Grant Number GR 14–0963) and RCSI’s Summer Research School Programme; Science Foundation Ireland (SFI) under Grant Number SFI/12/RC/2278; and the European Union for a Marie Curie European Reintegration Grant under H2020 (Project Reference 659715). C.R.L. is a recipient of a National Institutes of Health T32 Award in Oncology Training Fellowship at The Ohio State University Comprehensive Cancer Center, 5T32CA009338–37. C.E.C. acknowledges the National Science Foundation (NSF) under Grant CMMI-1235060 and the Center for Emergent Materials at The Ohio State University, an NSF Materials Research Science and Engineering Center (Award DMR-0820414).
This is the peer reviewed version of the following article: Kearney CJ, Lucas CR, O'Brien FJ, Castro CE. DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior. Advanced Materials. 2016;28(27):5509-24, which has been published in final form at DOI: 10.1002/adma.201504733. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Kearney CJ, Lucas CR, O'Brien FJ, Castro CE. DNA Origami: Folded DNA-Nanodevices That Can Direct and Interpret Cell Behavior. Advanced Materials. 2016;28(27):5509-24.