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Depressive symptoms in persons with acute coronary syndrome: specific symptom scales and prognosis

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journal contribution
posted on 22.11.2019 by Frank Doyle, Ronán Conroy, Hannah McGee, Mary Delaney

Objective To determine which particular depressive symptom scales, derived from three scales, predicted poorer prognosis in persons with acute coronary syndrome (ACS). Methods Hospitalised ACS patients (n=408) completed questionnaires (depression, vital exhaustion). Mokken scaling derived unidimensional scales. Major cardiac events (cardiac mortality, ACS, unplanned revascularisation) were assessed at median 67 weeks post-event. Results Only depressive symptoms of fatigue-sadness predicted prognosis in univariate (hazard ratio [HR]=1.8, 95% CI 1.1–3.0, p=0.025) and multivariate analysis (HR=1.8, 95% CI 1.1–2.9, p=0.025). Symptoms of anhedonia (HR=1.6, 95% CI 0.9–2.8, p=0.102) and depressive cognitions (HR=1.3, 95% CI 0.7–2.2, p=0.402) did not. Conclusion Symptoms of fatigue-sadness, but not other symptoms, were associated with increased risk of major cardiac events. Depression should be considered as a multidimensional, rather than a unidimensional, entity when designing interventions.

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This article is also available at http://www.jpsychores.com/ or http://www.sciencedirect.com/science/journal/00223999

Published Citation

Doyle F, Conroy R, McGee H, Delaney M. Depressive symptoms in persons with acute coronary syndrome: specific symptom scales and prognosis. Journal of Psychosomatic Research 2010 Feb;68(2):121-30.

Publication Date

01/01/2010

PubMed ID

20105694

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