Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropyl.pdf (2.51 MB)
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Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing.

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posted on 23.11.2019 by Marcello Iacono, Damian Connolly, Andreas Heise

Polymers are interesting housing materials for the fabrication of inexpensive monolithic chromatography and solid phase extraction (SPE) devices. Challenges arise when polymeric monoliths are formed in non-conical, cylindrical tubes of larger diameter due to potential monolith detachment from the housing wall resulting in loss of separation performance and mechanical stability. Here, a two-step protocol is applied to ensure formation of robust homogeneous methacrylate monolith in polypropylene (PP) tubing with a diameter of 2.0 mm. Detailed Fourier-transform infrared (FTIR) spectroscopic analysis and Scanning Electron Microscopy (SEM) imaging confirm the successful pre-modification of the tubing wall with an anchoring layer of cross-linked ethylene dimethacrylate (EDMA). Subsequent formation of an EDMA-glycidyl methacrylate (GMA) monolith in the PP tube resulted in a homogeneous monolithic polymer with enhanced mechanical stability as compared to non-anchored monoliths.

Funding

This work was supported by funding from Science Foundation Ireland (07/IN1/B1792). M. I. gratefully acknowledges support from the Biomedical Diagnostic Institute (BDI) and the Irish Separation Science Cluster (ISSC)

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This article is also available at http://www.mdpi.com/1996-1944/9/4/263

Published Citation

Iacono M, Connolly D, Heise A. Fabrication of a GMA-co-EDMA Monolith in a 2.0 mm i.d. Polypropylene Housing. Materials. 2016;9:263.

Publication Date

31/03/2016

Publisher

MDPI

PubMed ID

28773385

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